Metabolic Diet Amino

Amino, the most advanced cutting-edge amino acid formulation on the market today, maximizes protein synthesis by providing you with a quick and potent boost of anabolic and anticatabolic hormones and amino acids. The high systemic levels of amino acids and other synergistic ingredients provided by Amino has a direct effect on increasing protein synthesis, and at the same time increases systemic levels of the potent anabolic hormones and growth factors, including insulin, testosterone, growth hormone and insulin-like growth factor I (IGF-1).

Amino contains the exact mix and quantity of essential amino acids that in recent research studies maximized post exercise protein synthesis. (for example, Borsheim E, Tipton KD, Wolf SE, Wolfe RR. Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 2002 Oct;283(4):E648-57. ? for other studies, see the list of references for Amino).

Amino also contains the conditionally and non-essential amino acids that have been shown to be most used for protein synthesis in muscle (serving not only as direct substrates but also sparing the conversion of these amino acids from the essential ones). This combination is enough to make Amino the best amino acid supplement out there. As well, Amino contains my Amino Proprietary Complex (APC), a proprietary blend of several ingredients that maximizes mitochondrial anaplerotic flux in the TCA cycle resulting in increased ATP production and increased energy availability for protein synthesis and other functions, including the formation of phosphocreatine.

The APC formula in Amino contains measured amounts of several anapleurotic and other ingredients that impact on TCA flux and which I feel, maximize mitochondrial metabolism, increase aerobic energy production, and enhance insulin and growth hormone/IGF-I secretion and formation. While many people feel that various feedback mechanisms act to limit simultaneous increases in hormones and growth factors such as insulin, GH, IGF-I, testosterone, etc. In fact this is not the case under specific environments.

For example increasing IGF-I does not seem to decrease GH stimulation by secretogogues such as arginine.i These effects are secondary to both direct and indirect influences of the various ingredients on TCA flux through the increase of TCA intermediates such as succinate,ii and malate/pyruvate shuttleiii and both established and novel anaplerotic reactions. As well the APC also results in increased levels of both oxoglutaric acid and glutamate, the former as an anaplerotic TCA intermediate that seems to be glutamine driven as against the logical glutamate, and the latter as a compound that decreases cataplerosis while at the same time indirectly increases insulin secretion. The overall increase in anapleurotic flux produces an increase in aerobic energy production, insulin secretion, and protein synthesis, and results in an increased adaptive response, a surge in skeletal muscle cell growth, increased fat loss, and improved recovery.

One more point about Amino. Unlike some other amino acid products, there's no L-tryptophan in it. Although these products actually highlight their use of tryptophan, I specifically left it out of the Amino formulation for two very good reasons. Reason number one involves the role L-tryptophan has in muscle anabolism. While it is true that tryptophan stimulates protein synthesis when it's part of an essential amino acid (EAA) or mixed amino acid (AA) mixture, it's effects are mainly on liver protein synthesis.

In recent studies,iv L-tryptophan was not included in the amino acid mix because it (along with tyrosine) has negligible effects on skeletal muscle protein synthesis and in fact, because of its effects on hepatic protein synthesis, is counterproductive if your goal is to maximize muscle protein synthesis. Increasing liver protein synthesis is robbing Peter (muscle) to pay Paul (liver).

The other reason that some people use tryptophan in a post exercise AA mixture is that it increases serotonin levels and as such provides a relaxing effect after training. This is not true since the other large neutral amino acids such as the BCAAs compete with tryptophan for transport across the blood-brain barrier and hence CNS levels of tryptophan do not increase significantly, leaving more of the tryptophan in the system - which is exactly what we don't want if the aim is to maximize skeletal muscle protein synthesis. This of course takes us back to reason number one.

In summary, Amino, used immediately after training is an easy to take, easy on the stomach, source of amino acids and other ingredients that kicks protein synthesis into high gear so you can begin taking advantage of that post-training window of opportunity. Amino is formulated to provide a square wave increase in the availability of blood amino acids and synergistic compounds within minutes after ingestion, and a measurable increase in muscle protein synthesis within less than half an hour ? much faster than other post exercise supplements.

The amino acid, peptide blend, and special ingredients in Amino work together synergistically to immediately increase blood amino acid levels, insulin sensitivity and insulin levels, as well as growth hormone, IGF-I and testosterone levels, resulting in increased muscle protein synthesis which maximizes the anabolic and fat burning effects of exercise and combats overtraining. Amino can also be used throughout the day to give a rapid pulsed increase in amino acids and anabolic hormones that leads to short burst increases in muscle protein synthesis. Research has shown that pulses of high levels of amino acids is much more effective in increasing protein synthesis than sustained high levels. The bottom line is that the new Amino will stimulate GH and insulin levels and protein synthesis, decrease muscle degradation and result in an anabolic kick whenever it's used, especially right after training.

MD+ Amino

• 1. Maximizes protein synthesis and decreases muscle breakdown after training and anytime it's used.
• 2. Maximizes the anabolic and fat burning effects of exercise.
• 3. Enhances recovery.